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Imaging in and through scattering media is of immediate interest in biomedical research through to everyday clinical practice. In living tissue, the scattering and absorption of light by various molecules such as hemoglobin, pigments or water results in signal attenuation and a limited imaging depth caused by the distortion of the amplitude and phase of the (light) wave. Light scattering works in a similar way with a pane of frosted glass, which obstructs and distorts our vision (see image). Technologically advanced light modulators (SLM) can correct the light distortion and restore the original image.
An example of a biomedical application for image acquisition using scattering media is deep tissue imaging. In this process, optical information is obtained from deep tissue layers, normal and diseased tissue can be distinguished, as can cell types, biomarker profiles, biological structures and processes in living organisms.
In the medical field, endoscopy is one of the most important imaging methods for human medical diagnostics and for carrying out minimally invasive surgical procedures. Endoscopy means “looking at the inside”.
The use of modern optical procedures and digitalization have been driving the technological development of medical endoscopy for many years. Even the smallest findings in the millimetre range can be detected and characterized thanks to the high image resolution. The use of light of different wavelengths helps to obtain important information on the vascular supply of the mucous membranes, which was otherwise only possible through surgery with tissue removal. Endoscopic micro-optics also allow a digital view into tiny duct systems (bile duct, pancreatic duct).
As described above, a fundamental requirement for imaging in and through scattering media is to control the intensity and phase of the light as quickly and precisely as possible. Our key components for this are so-called spatial light modulators (SLM), programmable components that are used to adjust the optical wavefront of the light Figure right. In combination with endoscopes, they allow an even more precise view behind vessel walls and into tissue layers without damaging or injuring them.
The range of applications for MEMS-based imaging in the OASYS project is very extensive, and we have broken down some of the use cases below:
Haben Sie Fragen zur technischen Umsetzung in Ihrem Unternehmen, suchen Sie nach einer speziellen Lösung für ein konkretes Anwendungsproblem, dann kontaktieren Sie uns. Gerne evaluieren wir mit Ihnen vorab Ihren Anwendungsfall und führen einen kostenlosen Technologietransfer-Check durch. Bitte beachten Sie, dass diese Vorab-Einschätzung kein Ersatz für eine Machbarkeitsstudie darstellt.
DOI:
White Paper
Cluster hyperspectral imaging
Cluster optical imaging in the biosciences
